Difference between revisions of "Prion"
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==Full Title or Meme== | ==Full Title or Meme== | ||
| − | Originally an infection vector caused by a misfolded protein that can cause that same misfolding wherever it goes. Can also be used in computer system were a data element is changed in such a way as to cause a failure of the program the depends on a correct value for that data element. | + | Originally an infection vector caused by a [https://en.wikipedia.org/wiki/Prion misfolded protein] that can cause that same misfolding wherever it goes. Can also be used in computer system were a data element is changed in such a way as to cause a failure of the program the depends on a correct value for that data element. |
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==Context== | ==Context== | ||
* In medicine [[Prion]]s are a type of intrinsically disordered protein that continuously changes conformation unless bound to a specific partner, such as another protein. Once a prion binds to another in the same conformation, it stabilizes and can form a fibril, leading to abnormal protein aggregates called amyloids. These amyloids accumulate in infected tissue, causing damage and cell death. The structural stability of prions makes them resistant to denaturation by chemical or physical agents, complicating disposal and containment, and raising concerns about iatrogenic spread through medical instruments. | * In medicine [[Prion]]s are a type of intrinsically disordered protein that continuously changes conformation unless bound to a specific partner, such as another protein. Once a prion binds to another in the same conformation, it stabilizes and can form a fibril, leading to abnormal protein aggregates called amyloids. These amyloids accumulate in infected tissue, causing damage and cell death. The structural stability of prions makes them resistant to denaturation by chemical or physical agents, complicating disposal and containment, and raising concerns about iatrogenic spread through medical instruments. | ||
Revision as of 11:06, 2 October 2024
Full Title or Meme
Originally an infection vector caused by a misfolded protein that can cause that same misfolding wherever it goes. Can also be used in computer system were a data element is changed in such a way as to cause a failure of the program the depends on a correct value for that data element.
Context
- In medicine Prions are a type of intrinsically disordered protein that continuously changes conformation unless bound to a specific partner, such as another protein. Once a prion binds to another in the same conformation, it stabilizes and can form a fibril, leading to abnormal protein aggregates called amyloids. These amyloids accumulate in infected tissue, causing damage and cell death. The structural stability of prions makes them resistant to denaturation by chemical or physical agents, complicating disposal and containment, and raising concerns about iatrogenic spread through medical instruments.
- In computer systems major system failure was caused when CrowdStrike issued an update to their
